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pregnancy outcomes of assisted reproduction treatment in Spain, Year 2008


The Health Interest Group Embryonic English Fertility Society published in the Journal Fertility gestational outcomes of assisted reproduction treatment (ART) in Spain, Year 2008. This paper covers for the first time in Spain a descriptive analysis of the results of 5,303 pregnancies collected after fertility treatments. Were considered for the job as principal variables of age of pregnant women, multiple gestation and type of ART. These variables were related to pregnancy loss, prematurity, type of birth, weight, mortality and malformations in newborns. No substantial differences were found regarding a lo descrito en la literatura en la población general. La incidencia de prematuridad en las gestaciones únicas es comparable a la descrita por la Sociedad Española de Ginecología y Obstetricia (SEGO) para la población española. La incidencia de cesáreas en las gestaciones únicas es el doble de la descrita en España en el último informe SEGO (2004), y está probablemente relacionado con la edad de la mujer. El porcentaje de malformaciones es del 0.99% y se encuentra por debajo del descrito en la población española durante el periodo 1980-2004.

El trabajo está firmado por
Sylvia Fernández-Shaw, Isidoro Bruna, Gemma Arroyo, María Carrera, José María Gris, Manuel Fernández, Raquel Herrero, Federico Perez Milan, Felipe del Río, María José Torello, Victoria Verdú and Elisabetta Ricciarelli.

Source:
Revista Iberoamericana de Fertilidad

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In patients with endometriosis oral contraceptives may improve the outcome before an in vitro fertilization treatment.

The endometriosis patients receiving prior treatment with contraceptives for 6 to 8 weeks can achieve better pregnancy rates in in vitro fertilization (IVF), according to a study recently published in Fertility & Sterility.

is a pilot study at two centers in Paris and Geneva, led by Dr. De Ziegler. In the same have included a total of 795 patients, of which 296 were diagnosed with endometriosis, surgery or ultrasound, and 509 did not have endometriosis and performed in vitro fertilization treatment for other diagnoses (control group).

The patients were further divided into two groups: group 1 included those who received pre-treatment with oral contraceptive (426 endometriosis and 114 controls), while in group 2 started IVF treatment directly (83 with endometriosis and 172 controls). Initially

difference in age between groups 1 (younger), and 2, although statistically significant, was small and not very relevant. In assessing the results of cycles all groups were further divided into ≤ 37 and ≥ 38 years. A higher number of oocytes retrieved in patients with endometriosis who took OCs for both age groups, as well as embryos. The mean number of embryos transferred was similar in both groups, although patients taking OCs previously frozen embryos. The clinical pregnancy rate was much higher among patients with endometriosis who took OCs compared to those who do not, even with numbers similar to those without endometriosis.

Previous studies have shown a possible beneficial effect of ovarian rest the months prior to IVF in patients with endometriosis, mainly by using drug group GnRH agonists. The main advantage of OCs with regard to them is the fewest side effects. Given the methodological limitations of the study, these promising results must be confirmed in further studies, preferably clinical trials.

Source: Fertil Steril 2010, 94:2796-9