The endometriosis patients receiving prior treatment with contraceptives for 6 to 8 weeks can achieve better pregnancy rates in in vitro fertilization (IVF), according to a study recently published in Fertility & Sterility. is a pilot study at two centers in Paris and Geneva, led by Dr. De Ziegler. In the same have included a total of 795 patients, of which 296 were diagnosed with endometriosis, surgery or ultrasound, and 509 did not have endometriosis and performed in vitro fertilization treatment for other diagnoses (control group).
The patients were further divided into two groups: group 1 included those who received pre-treatment with oral contraceptive (426 endometriosis and 114 controls), while in group 2 started IVF treatment directly (83 with endometriosis and 172 controls). Initially
difference in age between groups 1 (younger), and 2, although statistically significant, was small and not very relevant. In assessing the results of cycles all groups were further divided into ≤ 37 and ≥ 38 years. A higher number of oocytes retrieved in patients with endometriosis who took OCs for both age groups, as well as embryos. The mean number of embryos transferred was similar in both groups, although patients taking OCs previously frozen embryos. The clinical pregnancy rate was much higher among patients with endometriosis who took OCs compared to those who do not, even with numbers similar to those without endometriosis.
Previous studies have shown a possible beneficial effect of ovarian rest the months prior to IVF in patients with endometriosis, mainly by using drug group GnRH agonists. The main advantage of OCs with regard to them is the fewest side effects. Given the methodological limitations of the study, these promising results must be confirmed in further studies, preferably clinical trials.
Source: Fertil Steril 2010, 94:2796-9
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